Event Title

The Effects of Pterostilbene on Amyloid-β Aggregation in C. Elegans (cl4176)

Presenter Information

Adam Tangarone, Chemistry

Faculty Sponsor(s)

Susan Swope

Location

Hartman Union Building Courtroom

Presentation Type

Event

Start Date

4-28-2017 4:00 PM

End Date

4-28-2017 5:00 PM

Abstract

Leading risk factors for Alzheimer’s disease are oxidative stress and toxicity of the protein Amyloid-β (Aβ). Pterostilbene (PtS) is the primary antioxidant component in blueberries, and has recently drawn attention as a potential mediator and preventer against cognitive decline. This study assessed the effects of PtS on oxidative stress and Aβ aggregation through the lifespan and paralysis of transgenic Caenorhabditis elegans at different concentrations. The strain of C. elegans used in this study was cl4176, which expresses the human Aβ(1-42). The results showed that when fed relatively high concentrations (500μM), their lifespans closely paralleled that of the untreated C. elegans. As concentration decreased to 100μM however, the C. elegans’ lifespan dramatically increased. These findings demonstrate the potential for positive mediation against Aβ toxicity and oxidative stress.

This document is currently not available here.

Share

COinS
 
Apr 28th, 4:00 PM Apr 28th, 5:00 PM

The Effects of Pterostilbene on Amyloid-β Aggregation in C. Elegans (cl4176)

Hartman Union Building Courtroom

Leading risk factors for Alzheimer’s disease are oxidative stress and toxicity of the protein Amyloid-β (Aβ). Pterostilbene (PtS) is the primary antioxidant component in blueberries, and has recently drawn attention as a potential mediator and preventer against cognitive decline. This study assessed the effects of PtS on oxidative stress and Aβ aggregation through the lifespan and paralysis of transgenic Caenorhabditis elegans at different concentrations. The strain of C. elegans used in this study was cl4176, which expresses the human Aβ(1-42). The results showed that when fed relatively high concentrations (500μM), their lifespans closely paralleled that of the untreated C. elegans. As concentration decreased to 100μM however, the C. elegans’ lifespan dramatically increased. These findings demonstrate the potential for positive mediation against Aβ toxicity and oxidative stress.