Event Title

Elderberry Extract Modifies the Proteostasis Network and Extends Lifespan in C. elegans

Faculty Sponsor(s)

Susan Swope

Abstract

The degradation of the proteostasis network (PN) is indicative of several age-related diseases. A common theme in these diseases is the buildup of the toxic amyloid beta (Aβ) oligomer. Treatment of elderberry extract (EBE) provides significant lifespan extension to C.elegans; however the mechanism of lifespan extension has remained unclear. Several genetic variations in the Insulin/IGF-1 Signaling (IIS) have also lead to a significant extension of lifespan. Thus, knockdown of several genes in the IIS Pathway may elucidate the desired target for lifespan extension. Western blot analysis will demonstrate the effectiveness of EBE treatment by displaying reduction of Aβ. Understanding the mechanism behind EBE’s effect may open new doorways to preventative treatments of many age-related diseases.

Location

Hartman Union Building Courtroom

Start Date

5-2-2019 3:00 PM

End Date

5-2-2019 4:00 PM

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May 2nd, 3:00 PM May 2nd, 4:00 PM

Elderberry Extract Modifies the Proteostasis Network and Extends Lifespan in C. elegans

Hartman Union Building Courtroom

The degradation of the proteostasis network (PN) is indicative of several age-related diseases. A common theme in these diseases is the buildup of the toxic amyloid beta (Aβ) oligomer. Treatment of elderberry extract (EBE) provides significant lifespan extension to C.elegans; however the mechanism of lifespan extension has remained unclear. Several genetic variations in the Insulin/IGF-1 Signaling (IIS) have also lead to a significant extension of lifespan. Thus, knockdown of several genes in the IIS Pathway may elucidate the desired target for lifespan extension. Western blot analysis will demonstrate the effectiveness of EBE treatment by displaying reduction of Aβ. Understanding the mechanism behind EBE’s effect may open new doorways to preventative treatments of many age-related diseases.